Indole-3-Carboxaldehyde → Oncrasin 1

HRID 2394440Notes

Reaction equation

HRID 2394440 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([CH:19]=[O:20])=[CH:11]1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([CH:19]=[O:20])=[CH:11]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 693291-(Bromomethyl)-4-chlorobenzene

Product 1

HCID 872445Oncrasin 1Yield 92%

Procedure

The same procedures used in Example 1 were repeated except for using 2.98 g of 4-chlorobenzyl bromide and 2.00 g of indole-3-carbaldehyde as a starting material to give 3.42 g of 1-(4-chlorobenzyl)indole-3-carbaldehyde as pale yellow crystals. The yield thereof was found to be 92%.

Sources & evidence

ORD record
ord-6775f21ae8924d4c93f01ed5186822d3
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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