Indole-3-Carboxaldehyde → HCID 883381, compound

HRID 2394441Notes

Reaction equation

HRID 2394441 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([CH:21]=[O:22])=[CH:13]1>>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]([CH:21]=[O:22])=[CH:13]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 660114-Nitrobenzyl bromide

Product 1

HCID 883381HCID 883381, compoundYield 61.6%

Procedure

The same procedures used in Example 7 were repeated except for using 5.96 g of 4-nitrobenzyl bromide and 2.00 g of indole-3-carbaldehyde as a starting material to give 2.38 g of 1-(4-nitrobenzyl) indole-3-carbaldehyde as pale brown crystals. The yield thereof was found to be 62%.

Sources & evidence

ORD record
ord-3790306854584d739db51b29dedb4ee8
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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