Indole-3-Carboxaldehyde → HCID 18973550, compound

HRID 2394444Notes

Reaction equation

HRID 2394444 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1.CS(O[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:20][CH:19]=1)(=O)=O>>[CH2:25]([O:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]([CH:10]=[O:11])=[CH:2]2)=[CH:23][CH:22]=1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 18973462HCID 18973462, compound

Product 1

HCID 18973550HCID 18973550, compound

Procedure

The same procedures used in Example 1 were repeated except for using 435 mg of indole-3-carbaldehyde and 4-benzyloxybenzyl methanesulfonate in place of the benzyl bromide used in Example 1 to give 626 mg of 1-(4-benzyloxybenzyl)indole-3-carbaldehyde as colorless crystals. The yield thereof was found to be 61%.

Sources & evidence

ORD record
ord-603dc0aba62a4232b32214a9cba821cf
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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