4-Fluorobenzenesulfonyl chloride → HCID 18973285, compound

HRID 2394446Notes

Reaction equation

HRID 2394446 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]([CH:10]=[O:11])=[CH:2]2)(=[O:21])=[O:20])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 10256Indole-3-Carboxaldehyde

Product 1

HCID 18973285HCID 18973285, compound

Procedure

The same procedures used in Example 17 were repeated except for using 870 mg of indole-3-carbaldehyde and 4-fluorobenzenesulfonyl chloride instead of the benzenesulfonyl chloride used in Example 17 to give 1.73 g of 1-(4-fluorobenzenesulfonyl)indole-3-carbaldehyde as brown crystals. The yield thereof was found to be 95%.

Sources & evidence

ORD record
ord-74594cdbfcc243feb9300bce490a56fb
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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