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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2394449Generated: October 28, 2026

Styrene Oxide → 1-(2-Hydroxy-2-phenylethyl)-1H-indole-4-carboxylic acid

https://huagongshe.com/reaction/2394449

Reaction equation

Participants

RoleNameHCIDCharge
ReactantStyrene OxideHCID 7276—
Reactantmethyl 1H-indole-4-carboxylateHCID 2733668—
Product1-(2-Hydroxy-2-phenylethyl)-1H-indole-4-carboxylic acidHCID 1897336456.9%

Reaction Steps

The same procedures used in Example 1 were repeated except for using 4.53 g of styrene oxide and 6.00 g of methyl indole-4-carboxylate as a starting material to give 5.48 g of 1-(2-hydroxy-2-phenylethyl) indole-4-carboxylic acid as a yellow amorphous substance. The yield thereof was found to be 57%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05811439
Source datasetuspto-grants-1998_09
ORD IDord-3eb7a71509ff41f7a2d7dc1b3f7669eb
Source noteuspto-grants-1998_09