Methyl iodide → HCID 18973353, compound

HRID 2394455Notes

Reaction equation

HRID 2394455 reaction equation
[CH3:1]I.[OH:3][CH:4]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][CH:11]=[C:10]([CH:15]=[O:16])[C:9]=2[CH:8]=[CH:7]1>>[CH3:1][O:3][CH:4]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][CH:11]=[C:10]([CH:15]=[O:16])[C:9]=2[CH:8]=[CH:7]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18973329HCID 18973329, compound

Product 1

HCID 18973353HCID 18973353, compoundYield 93%

Procedure

The same procedures used in Example 324 were repeated except for using 113 mg of methyl iodide and 189 mg of 1-(2-hydroxy-2-phenylethyl)indole-4-carbaldehyde prepared in Example 321 as a starting material to give 185 mg of 1-(2-methoxy-2-phenylethyl)indole-4-carbaldehyde as a yellow oily substance. The yield thereof was found to be 93%.

Sources & evidence

ORD record
ord-1c4dcb23f0d848a5872661ab01f8e22a
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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