N-(n-propyl)trichloroacetamide → 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-propylaminocarbonyl-aminosulfonyl)-7-methoxychroman

HRID 2394459Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8].[CH2:30]([NH:33][C:34](=[O:39])C(Cl)(Cl)Cl)[CH2:31][CH3:32]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21]([NH:22][C:34]([NH:33][CH2:30][CH2:31][CH3:32])=[O:39])(=[O:23])=[O:24])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8]

Participants

Reactant 2

HCID 4287575N-(n-propyl)trichloroacetamide

HCID 110484644-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman

Product 1

HCID 189736264-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-propylaminocarbonyl-aminosulfonyl)-7-methoxychroman

Procedure

4-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-propylaminocarbonyl-aminosulfonyl)-7-methoxychroman ##STR33## 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-propylaminocarbonylaminosulfonyl)-7methoxychroman is prepared analogously to Example 1 from 4-(5Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman and N-(n-propyl)trichloroacetamide. Melting point: 159°-160° C.

Sources & evidence

ORD record: ord-966d531fafc44527bcc4f06801a5ee4f
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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