Ethyl isothiocyanate → 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminothiocarbonylaminosulfonyl)-7-methoxychroman

HRID 2394460Notes

Reaction equation

HRID 2394460 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8].[CH2:30]([N:32]=[C:33]=[S:34])[CH3:31]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21]([NH:22][C:33]([NH:32][CH2:30][CH3:31])=[S:34])(=[O:23])=[O:24])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8]

Participants

3

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 110484644-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman

Product 1

HCID 544060914-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminothiocarbonylaminosulfonyl)-7-methoxychroman

Procedure

4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminothiocarbonylaminosulfonyl)-7-methoxychroman ##STR35## 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminothiocarbonylaminosulfonyl)-7-methoxychroman is synthesize as described in Example 4 from 4-(5-chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman and ethyl isothiocyanate. Melting point: 196°-197° C.

Sources & evidence

ORD record
ord-b8d992d9832746e6a1ff13370aa3a110
Source dataset
uspto-grants-1998_09
Patent number
US05811448

Reaction notes

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