2,2,2-Trichloro-n-methylacetamide → HCID 18973639, compound

HRID 2394463Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:29][CH3:30])=[C:6]([CH:28]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH2:26][CH3:27])=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8].[CH3:31][NH:32][C:33](=[O:38])C(Cl)(Cl)Cl>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:29][CH3:30])=[C:6]([CH:28]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH2:26][CH3:27])=[C:18]([S:21]([NH:22][C:33]([NH:32][CH3:31])=[O:38])(=[O:23])=[O:24])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8]

Participants

Reactant 2

HCID 2486522,2,2-Trichloro-n-methylacetamide

HCID 18973636HCID 18973636, compound

Product 1

HCID 18973639HCID 18973639, compound

Procedure

4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7-ethoxychroman ##STR39## 4-(5-Chloro-2-methoxy-benzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7ethoxychroman is prepared as described in Example 1 from 4-(5-Chloro-2-methoxybenzamidomethyl)6-sulfamoyl-7-ethoxy-chroman and N-methyltrichloroacetamide. Melting point: 207°-208° C.

Sources & evidence

ORD record: ord-6bb1f1b10da6411f8d35d28c94ce96df
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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