Propyl Isothiocyanate → HCID 57136990, compound

HRID 2394467Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:29])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH3:28])=[C:20]([S:23](=[O:26])(=[O:25])[NH2:24])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2].[CH2:30]([N:33]=[C:34]=[S:35])[CH2:31][CH3:32]>>[CH2:1]([C:3]1[C:4](=[O:29])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH3:28])=[C:20]([S:23]([NH:24][C:34]([NH:33][CH2:30][CH2:31][CH3:32])=[S:35])(=[O:25])=[O:26])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2]

Participants

Reactant 2

HCID 69403Propyl Isothiocyanate

HCID 18973614HCID 18973614, compound

Product 1

HCID 57136990HCID 57136990, compound

Procedure

4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(n-propylaminothiocarbonylaminosulfonyl)-7-methoxychroman ##STR49## 4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(n-propylaminothiocarbonylaminosulfonyl)-7-methoxychroman is prepared as described in Example 14 from 4-((3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-sulfamoyl-7-methoxychroman and n-propyl isothiocyanate. Melting point: 96°-98° C.

Sources & evidence

ORD record: ord-cf9efc60df7f449986fb3611a552f6fd
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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