Isopropyl Isothiocyanate → HCID 57167563, compound

HRID 2394468Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:29])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH3:28])=[C:20]([S:23](=[O:26])(=[O:25])[NH2:24])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2].[CH:30]([N:33]=[C:34]=[S:35])([CH3:32])[CH3:31]>>[CH2:1]([C:3]1[C:4](=[O:29])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH3:28])=[C:20]([S:23]([NH:24][C:34]([NH:33][CH:30]([CH3:32])[CH3:31])=[S:35])(=[O:25])=[O:26])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2]

Participants

Reactant 2

HCID 75263Isopropyl Isothiocyanate

HCID 18973614HCID 18973614, compound

Product 1

HCID 57167563HCID 57167563, compound

Procedure

4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(isopropylaminothiocarbonylaminosulfonyl)-7-methoxychroman ##STR50## 4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(isopropylaminothiocarbonylaminosulfonyl)-7-methoxychroman is synthesized following Example 14 starting from 4-((3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)methyl)6-sulfamoyl-7-methoxychroman and isopropyl isothiocyanate. Melting point: 153° C.

Sources & evidence

ORD record: ord-effabb3d7e964486a35229ed9e6290f9
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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