Methyl isothiocyanate → HCID 57283766, compound

HRID 2394469Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:30])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH2:28][CH3:29])=[C:20]([S:23](=[O:26])(=[O:25])[NH2:24])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2].[CH3:31][N:32]=[C:33]=[S:34]>>[CH2:1]([C:3]1[C:4](=[O:30])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:27][CH2:28][CH3:29])=[C:20]([S:23]([NH:24][C:33]([NH:32][CH3:31])=[S:34])(=[O:25])=[O:26])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2]

Participants

Reactant 2

HCID 11167Methyl isothiocyanate

HCID 18973664HCID 18973664, compound

Product 1

HCID 57283766HCID 57283766, compound

Procedure

4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)methyl)-6-(methylaminothiocarbonyl aminosulfonyl)-7-ethoxychroman ##STR53## 4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(methylaminothiocarbonylaminosulfonyl)-7-ethoxychroman is synthesized analogously to Example 14 from 4-((3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-sulfamoyl-7-ethoxychroman and methyl isothiocyanate. Melting point: 178° C.

Sources & evidence

ORD record: ord-f5e2c713536240079d99875b9b039ced
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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