Hydrochloric Acid → HCID 18973664, compound

Participants

Reaction Steps

2.16 ml (0.027 mol) of ethyl iodide are added to a suspension of 9 g (0.022 mol) of 4-((3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-methyl)-6-sulfamoyl-7-hydroxychroman and 6.1 g (0.044 mol) of potassium carbonate in 60 ml of acetone. After stirring under reflux for three hours, the mixture is introduced into ice/water and cautiously acidified with concentrated hydrochloric acid. The precipitate is filtered off with suction, washed several times with cold water, dried and recrystallized from ethanol/DMF. 4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-methyl)-6-sulfamoyl-7-ethoxychroman of melting point 192° C. is obtained.

Provenance & Evidence