4-Methylthiophene-2-sulfonyl chloride → HCID 57989979, compound

HRID 239496Notes

Reaction equation

HRID 239496 reaction equation
[NH2:1][C:2]1[C:3]([F:24])=[C:4]([C:8]2[N:9]=[C:10]([C:20]([CH3:23])([CH3:22])[CH3:21])[S:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH2:19])[N:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:25][C:26]1[CH:27]=[C:28]([S:31](Cl)(=[O:33])=[O:32])[S:29][CH:30]=1>>[NH2:19][C:15]1[N:14]=[C:13]([C:12]2[S:11][C:10]([C:20]([CH3:21])([CH3:23])[CH3:22])=[N:9][C:8]=2[C:4]2[C:3]([F:24])=[C:2]([NH:1][S:31]([C:28]3[S:29][CH:30]=[C:26]([CH3:25])[CH:27]=3)(=[O:33])=[O:32])[CH:7]=[CH:6][CH:5]=2)[CH:18]=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 134257144-Methylthiophene-2-sulfonyl chlorideHCID 579897094-[4-(3-Amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine

Product 1

HCID 57989979HCID 57989979, compound

Procedure

Following a procedure analogous to the procedure described in Intermediate 14 using 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine (80 mg, 0.233 mmol) and 4-methyl-2-thiophenesulfonyl chloride (50 mg, 0.256 mmol), the title compound was obtained as a white solid (59 mg, 47% yield). MS (ESI): 504 [M+H]+.

Sources & evidence

ORD record
ord-57d43be880f04193a2d207a6fd07519a
Source dataset
uspto-grants-2014_02
Patent number
US08642759B2

Reaction notes

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