HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-Bromo-3-chloro-3,4,4-trifluorobutanal | HCID 21836480 | — |
| Product | 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol | HCID 21836477 | — |
Reaction Steps
Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifluorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifluorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811578 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-12a69c608c4b43af9251cfec0a4f7f2f |
| Source note | uspto-grants-1998_09 |