3,4,4-Trifluorobut-3-en-1-ol → 3,4,4-Trifluoro-3-butenoic acid

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Reaction Steps

The first method involves hydrolysis of 4-bromo-1,1,2-trifluoro-1butene (II) with water in the presence of N-methyl pyrrolidinone to give 3,4,4-trifluoro-3-buten-1-ol (III), followed by Jones oxidation under conditions not previously known. These conditions are at a temperature of about 51°-54° C. In addition, the 3,4,4-trifluoro-3-buten-1-ol in acetone solvent and the Jones reagent are added to the reaction vessel simultaneously to afford 3,4,4-trifluoro-3-butenoic (IV) acid in 52% overall yield. ##STR3##

Provenance & Evidence