HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine hydrochloride → (E)-(RS)-3-[1-(2-dimethylamino-1-methyl-ethyl)-propenyl]-phenol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine hydrochloride | HCID 18974531 | — |
| Reactant | Sodium hydroxide methylene chloride | HCID 23721229 | — |
| Product | (E)-(RS)-3-[1-(2-dimethylamino-1-methyl-ethyl)-propenyl]-phenol hydrochloride | HCID 18974528 | 73% |
Reaction Steps
The base was released with dichloromethane/sodium hydroxide solution from (5), which was prepared according to Example 5, and after drying the solution dichloromethane was removed by distillation. Hydrochloride (6), which had a melting point of 80° C., was obtained in a yield of 73% theoretical from the base obtained, under the conditions given in Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811582 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-1fecc7ddaeca4c5b90458f480067f15b |
| Source note | uspto-grants-1998_09 |