HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-hex-3-enyl]-dimethylamine hydrochloride → (E)-(RS)-3-[1-(2-dimethylamino-1-methyl-ethyl)-but-1-enyl]-phenol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-hex-3-enyl]-dimethylamine hydrochloride | HCID 18974546 | — |
| Reactant | Sodium hydroxide methylene chloride | HCID 23721229 | — |
| Product | (E)-(RS)-3-[1-(2-dimethylamino-1-methyl-ethyl)-but-1-enyl]-phenol hydrochloride | HCID 18974509 | 86% |
Reaction Steps
The base was released with dichloromethane/sodium hydroxide solution from (14), which was prepared as in Example 13, and after drying the solution the dichloromethane was removed by distillation. Hydrochloride (17) was obtained, under the conditions given in Example 2, from the base thus obtained, in a yield of 86% theoretical and with a melting point of 214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811582 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-65bff384acb5459c9136a849ac102319 |
| Source note | uspto-grants-1998_09 |