Sodium hydroxide methylene chloride → HCID 86753142, compound

HRID 2394983Notes

Reaction equation

HRID 2394983 reaction equation
[Cl:1]CCl.[OH-].[Na+].Cl.C[O:8][C:9]1[CH:10]=[C:11](/[C:15](=[CH:22]\[CH2:23][CH3:24])/[CH:16]([CH3:21])[CH2:17][N:18]([CH3:20])[CH3:19])[CH:12]=[CH:13][CH:14]=1>>[ClH:1].[CH3:20][N:18]([CH3:19])[CH2:17][CH:16](/[C:15](/[C:11]1[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=1)=[CH:22]/[CH2:23][CH3:24])[CH3:21]

Participants

3

Reactant 2

HCID 23721229Sodium hydroxide methylene chlorideHCID 67663208HCID 67663208, compound

Product 1

HCID 86753142HCID 86753142, compoundYield 86%

Procedure

The base was released with dichloromethane/sodium hydroxide solution from (15), which was prepared as in Example 13, and after drying the solution the dichloromethane was removed by distillation. Hydrochloride (18) was obtained, under the conditions given in Example 2, from the base thus obtained, in a yield of 86% theoretical and with a melting point of 120°-121° C.

Workup

  1. customwas prepared as in Example 13
  2. dry with materialafter drying the solution the dichloromethane
  3. customwas removed by distillation

Sources & evidence

ORD record
ord-7b1740803fb44942acd88758347ea29a
Source dataset
uspto-grants-1998_09
Patent number
US05811582

Reaction notes

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