HCID 18974552, compound → HCID 18974513, compound

Participants

Reaction Steps

Starting from (RS)-3-dimethylamino-1-(3-methoxy-phenyl)-2-methyl-propan-1-one and methyl iodide, (2RS,3SR)-4-dimethylamino-2-(3-methoxy-phenyl)-3-methyl-butan-2-ol hydrochloride (23) was obtained, under the conditions given in Example 1 (1st step) and using ether as a solvent, in a yield of 46% and with a melting point of 178°-179° C. The base was released from (23) with dichloromethane/sodium hydroxide solution. After drying the solvent, the dichloromethane was distilled off under vacuum. 23.7 g (0.1 mole) of the base were reacted with diisobutylaluminium hydride as in Example 2. In this manner, 18.5 g (71% theoretical) of hydrochloride (22) were obtained with a melting point of 183°-184° C.

Provenance & Evidence