HCID 18974541, compound → HCID 18974556, compound

Participants

Reaction Steps

Starting from (RS)-1-dimethylamino-2,4-dimethyl-pentan-3-one and 1-bromo-3-methoxy-benzene, (2RS,3RS)-1-dimethylamino-3-(3-methoxy-phenyl)-2,4-dimethyl-pentan-3-ol hydrochloride (26) was obtained, under the conditions given in Example 1 (1st step), in a yield of 44% and with a melting point of 180°-181° C. 30 g (0.1 mole) of compound (26) were reacted with 450 ml of concentrated formic acid as in Example 5. The crude base obtained was introduced on to a column packed with silica gel. Elution with 7:1 diisopropyl ether/methanol gave 19 g base (77% theoretical) as a light yellow, viscous oil.

Provenance & Evidence