HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Methyl 4-(bromomethyl)-3-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 3-fluoro-4-methylbenzoate | HCID 18973767 | — |
| Catalyst | Azobisisobutyronitrile | HCID 6547 | — |
| Catalyst | Tungsten | HCID 23964 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Methyl 4-(bromomethyl)-3-fluorobenzoate | HCID 18766370 | 80% |
Reaction Steps
A mixture of methyl 3-fluoro-4-methylbenzoate (4.3 g), N-bromosuccinimide (4.5 g) and AIBN (20 mg) in carbon tetrachloride was irradiated with a 100 W Tungsten lamp at reflux for 1 hour. The mixture was filtered through diatomaceous earth, and evaporated to give methyl 3-fluoro-4-(bromomethyl)benzoate (5.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811459 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-2b4f5d38e757485d95a4b80e85e61197 |
| Source note | uspto-grants-1998_09 |