HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[3-(2-benzyloxyphenyl)-3-carbonyl-1(E)-propenyl]benzoate → Methyl 4-[2-(2-hydroxyphenyl)ethyl]-3-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[3-(2-benzyloxyphenyl)-3-carbonyl-1(E)-propenyl]benzoate | HCID 18973894 | — |
| Reactant | Methyl 4-[3-(2-hydroxyphenyl)-3-carbonylpropyl)benzoate | HCID 18974023 | — |
| Reactant | Methyl 4-[2-(2-benzyloxyphenyl)ethenyl)-3-fluorobenzoate | HCID 54449624 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 4-[2-(2-hydroxyphenyl)ethyl]-3-fluorobenzoate | HCID 18973971 | — |
Reaction Steps
Methyl 4-[2-(2-hydroxyphenyl)ethyl]-3-fluorobenzoate was synthesised from methyl 4-(2-(2-benzyloxyphenyl) ethenyl]-3-fluorobenzoate using the hydrogenation method described in Example 1 (for the conversion of 4-[3-(2-benzyloxyphenyl)-3-carbonyl-1(E)-propenyl]-benzoate to methyl 4-[3-(2-hydroxyphenyl)-3-carbonylpropyl)benzoate but using ethanol as the reaction solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811459 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-a7606064646a4987935039f0e1b80515 |
| Source note | uspto-grants-1998_09 |