Pyridine → HCID 18973928, compound

Participants

Reaction Steps

Trifluoroacetic anhydride (0.75 ml) was added to a mixture of 4-[2-benzyloxyphenethyl]-3-bromobenzamide (1.46 g) and pyridine (0.86 ml) in THF at -20° C. The mixture was stirred at ambient temperature for 18 hours, diluted with ethyl acetate and washed with water, dried (MgSO4), filtered and evaporated to dryness. The resulting residue was purified by MPLC on silica gel, eluting with CH2Cl2 to give 4-[2-benzyloxyphenethyl]-3-bromobenzonitrile as a white solid (1.34 g).

Provenance & Evidence