HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[3-(2-Hydroxy-4-cyanophenyl)propyl)benzoic acid → 4-[3-(2-Benzyloxy-4-cyanophenyl)propyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[3-(2-Hydroxy-4-cyanophenyl)propyl)benzoic acid | HCID 18973799 | — |
| Reactant | 2-Benzyloxy-4-cyanobenzaldehyde | HCID 18973906 | — |
| Reactant | 4-Carboxyphenethyltriphenylphosphonium bromide | HCID 22675527 | — |
| Reactant | 4-[3-(2-Benzyloxy-4-cyanophenyl)prop-1-enyl]benzoic acid | HCID 54218863 | — |
| Reactant | 4-[3-(2-Benzyloxy-4-cyanophenyl)prop-2-enyl]benzoic acid | HCID 70346687 | — |
| Product | 4-[3-(2-Benzyloxy-4-cyanophenyl)propyl]benzoic acid | HCID 18974106 | — |
Reaction Steps
2-Benzyloxy-4-cyanobenzaldehyde and 4-carboxyphenethyltriphenylphosphonium bromide were converted to a mixture of 4-[3-(2-benzyloxy-4-cyanophenyl)prop-2-enyl]benzoic acid and 4-[3-(2-benzyloxy -4-cyanophenyl)prop-1-enyl]benzoic acid by a similar method to that of Example 1, (G). The alkenes were converted to the required 4-[3-(2-hydroxy-4-cyanophenyl)propyl)benzoic acid by a similar method to that of Example 33, Footnote a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811459 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-b296f06ab11d48a88af06741038b2158 |
| Source note | uspto-grants-1998_09 |