Ethanolamine → HCID 18974079, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-[2-(2-benzyloxyphenyl)ethenyl]-benzenecarbonyl chloride (0.98 g) in dichloromethane (5 ml) was added dropwise to a solution of 2-aminoethanol (0.51 ml) in dichloromethane (15 ml) maintained at 0° C. The reaction mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The reaction mixture was washed with water (20 ml) and saturated aqueous sodium bicarbonate (20 ml) and dried. Evaporation of the solvent left a solid residue which was crystallised twice from methanol to give (E)-4-[2-(2-benzyloxyphenyl)ethenyl]-N-(2-hydroxyethyl)benzenecarboxamide (m.p. 149°-151° C.; yield 19%) containing about 4% of the related Z-isomer.

Provenance & Evidence