反应详情

To a solution of 2-benzyloxybenzyl alcohol (4.83 g) in diethyl ether (40 ml) was added dropwise, at 0° C., a solution of phosphorus tribromide (6.27 g) in diethyl ether (10 ml). The mixture was warmed to ambient temperature, diluted with diethyl ether (100 ml) and filtered through a pad of silica gel washing with 1 litre of diethyl ether. The combined organic solution was washed with saturated aqueous sodium hydrogen carbonate (100 ml) and brine (100 ml), dried (sodium sulphate), filtered and evaporated to give 2-benzyloxybenzyl bromide (5.88 g) as an oil.

1. filtrationfiltered through a pad of silica gel washing with 1 litre of diethyl ether
2. washThe combined organic solution was washed with saturated aqueous sodium hydrogen carbonate (100 ml) and brine (100 ml)
3. dry with materialdried (sodium sulphate)
4. filtrationfiltered
5. customevaporated