Ammonia → HCID 18973853, compound

Participants

Reaction Steps

A solution of methyl 6-[2-benzyloxy-5-bromophenethyl]-2-chloro-3-pyridinecarboxylate (2.0 g) in ethanol (60 ml) saturated with ammonia was heated at 177° C. under pressure for 6 hours. The solvent was evaporated and the residue subjected to chromatography on silica gel (7734). Two products were isolated. The first was eluted with 2.5% ethyl acetate/CH2Cl2 and the second with 5% MeOH/CH2Cl2. The first product was identified as a mixture of the methyl and ethyl esters of 6-[2-benzyloxy-5-bromophenethyl]-2-amino-3-pyridinecarboxylic aicd (0.3 g). The second produce was identified as the title compound (0.6 g) mpt. 142°-144° C.

Provenance & Evidence