HCID 23209946, compound → HCID 23209856, compound

Participants

Reaction Steps

Tert-butyl 4-[2-(pyrimidin-4(3 H)-one-5-yl)ethynyl]benzoate (0.59 g, 2.0 mmol) was dissolved in EtOAc (20 ml) and treated with palladium-on-carbon (0.30 g, 10%]. The reaction was placed under a hydrogen atmosphere and stirred overnight at ambient temperature. The reaction was filtered and evaporated to give tert-butyl 4-[2-(pyrimidin-4(3 H)-on-5-yl)ethyl]benzoate which was used without further purification (0.6 g, quantitative).

Provenance & Evidence