Methyl 4-[3-(3-benzyloxy-2-pyridyl)prop-2-enyl]benzoate → Methyl 4-[3-(3-hydroxy-2-pyridyl)propyl]benzoate

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Reaction Steps

Methyl 4-[3-(3-benzyloxy-2-pyridyl)prop-2-enyl]benzoate (1.5 g, 4.2 mmol) was dissolved in ethanol (5 ml) and EtOAc (15 ml), treated with 10% palladium on carbon (0.15 g) and placed under a hydrogen atmosphere. The mixture was stirred at ambient temperature for 10 hours and filtered and evaporated to give methyl 4-[3-(3-hydroxy-2-pyridyl)propyl]benzoate as a yellow oil (0.88 g, 77%).

Provenance & Evidence