Dimethylformamide → HCID 131720846, compound

Participants

Reaction Steps

A solution of 700 mg (1.31 mmol) of (6-tert.-butoxycarbonyl-aminomethyl-10-hexyl-3,7-dimethoxy-phenothiazin-4-yl)-acetic acid, 547 mg (1.44 mmol) of 1-benzotriazol-1-yl-N,N,N',N'-tetramethylnonium hexafluorophosphate (HBTU) and 488.1 mg (1.44 mmol) of Gly-Gly-Ala-Gly (SEQ ID NO:4)methyl ester hydrochloride in 5 ml of DMF was processed analogously to that described in Example 4.8.3., whereupon, after chromatography on silica gel with chloroform/methanol (9:1), 800 mg (77.6%) of (6-tert.-butoxycarbonyl-aminomethyl-10-hexyl-3,7-dimethoxy-phenothiazin-4-yl)-acetyl-glycyl-glycyl-L-alanyl-glycine methyl ester were obtained as an amorphous foam.

Provenance & Evidence