HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-isopropyl 3-furylboronate → N-(3-Chloro-4-fluorophenyl)-7-(furan-3-yl)quinazolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-isopropyl 3-furylboronate | HCID 13903463 | — |
| Reactant | 7-Bromo-4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt | HCID 18971362 | — |
| Product | N-(3-Chloro-4-fluorophenyl)-7-(furan-3-yl)quinazolin-4-amine | HCID 18971361 | 37% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 7-bromo-4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt was reacted with di-isopropyl 3-furylboronate to give 4-(3-chloro-4-fluoroanilino)-7-(3-furyl)quinazoline in 37% yield, m.p. 249°-250° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05814630 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-fe100b32981744abaaccb03a0572a68e |
| Source note | uspto-grants-1998_09 |