HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-isopropyl 2-furylboronate → 4-(3-Chloro-4-fluoroanilino)-7-(2-furyl)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-isopropyl 2-furylboronate | HCID 13701343 | — |
| Reactant | 7-Bromo-4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt | HCID 18971362 | — |
| Product | 4-(3-Chloro-4-fluoroanilino)-7-(2-furyl)quinazoline | HCID 18971357 | 36% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 7-bromo-4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt was reacted with di-isopropyl 2-furylboronate to give 4-(3-chloro-4-fluoroanilino)-7-(2-furyl)quinazoline in 36% yield, m.p.>250° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05814630 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-79da0ef9c9264b2a883b5614a6e2ce2e |
| Source note | uspto-grants-1998_09 |