HCID 135584247, compound → HCID 136051281, compound

HRID 2395253Notes

Reaction equation

HRID 2395253 reaction equation
[OH:1][C:2]1[C:7]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:6][C:5]([C:12]2[CH:16]=[C:15]([CH2:17][NH:18][C:19](=[O:25])[C:20]([O:22]CC)=[O:21])[O:14][N:13]=2)=[CH:4][C:3]=1[C:26]([CH3:29])([CH3:28])[CH3:27]>ClCCl>[OH:1][C:2]1[C:7]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:6][C:5]([C:12]2[CH:16]=[C:15]([CH2:17][NH:18][C:19](=[O:25])[C:20]([OH:22])=[O:21])[O:14][N:13]=2)=[CH:4][C:3]=1[C:26]([CH3:29])([CH3:28])[CH3:27]

Participants

3

Reactant 1

HCID 135584247HCID 135584247, compound

Product 1

HCID 136051281HCID 136051281, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.0 g (0.012 mol) of the product from Example 50 were hydrolyzed in analogy with Example 4b). The product, arising as an oil, was isolated by extraction with dichloromethane, washing with water and NaCl solution, drying and concentrating. The remaining amorphous product was crystallized from tert-butyl methyl ether/petroleum ether. Yield: 3.4 g.

Workup

  1. washwashing with water and NaCl solution
  2. customdrying
  3. concentrationconcentrating
  4. customThe remaining amorphous product was crystallized from tert-butyl methyl ether/petroleum ether

Sources & evidence

ORD record
ord-02247bae51dc4671b5a2906ef244904a
Source dataset
uspto-grants-1998_09
Patent number
US05814627

Reaction notes

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