2-Amino-4-chlorobenzoic acid → HCID 18971379, compound

HRID 2395274Notes

Reaction equation

HRID 2395274 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:15][C:16]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=O>>[Cl:25][C:23]1[CH:24]=[C:16]2[C:17]([C:18](=[O:20])[N:12]([S:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=3)(=[O:11])=[O:10])[C:13](=[O:14])[NH:15]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 18971526HCID 18971526, compound

Product 1

HCID 18971379HCID 18971379, compoundYield 20.1%

Procedure

1.14 g (5.49 mmol) of 3-cyanobenzenesulfonylisocyanate and 943 mg (5.50 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 399 mg of the above-identified compound (yield 20.0%). Properties: colorless crystal, Melting point: 225°-226° C., PMR (δppm, DMSO-d6); 7.13 (1H,s), 7.24 (1H,d), 7.89 (2H,m), 8.24 (1H,d), 8.43 (1H,d), 8.55 (1H,s), 11.76 (1H,br).

Sources & evidence

ORD record
ord-dfa9abdc924f40db853a575e32d08193
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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