2-Amino-4-chlorobenzoic acid → HCID 18971543, compound

HRID 2395275Notes

Reaction equation

HRID 2395275 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[CH3:8].[NH2:15][C:16]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=O>>[Cl:25][C:23]1[CH:24]=[C:16]2[C:17]([C:18](=[O:20])[N:12]([S:9]([C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)(=[O:11])=[O:10])[C:13](=[O:14])[NH:15]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 18971514HCID 18971514, compound

Product 1

HCID 18971543HCID 18971543, compoundYield 18.9%

Procedure

582 mg (2.76 mmol) of 3,4-dimethylbenzenesulfonylisocyanate and 473 mg (2.76 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 190 mg of the above-identified compound (yield 18.9%). Properties: colorless crystal, Melting point: >250° C., PMR (δppm, DMSO-d6): 2.33 (6H,s), 7.12 (1H,s), 7.23 (1H,d), 7.43 (1H,d), 7.84-7.91 (3H,m), 11.64 (1H,br).

Sources & evidence

ORD record
ord-d0831107d4204c518d14ccb2685d6d2f
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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