4-Chlorobenzenesulfonyl isocyanate → HCID 18971531, compound

HRID 2395277Notes

Reaction equation

HRID 2395277 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:14][C:15]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:16]=1[C:17](O)=[O:18]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]2[C:17](=[O:18])[C:16]3[C:15](=[CH:23][CH:22]=[C:21]([O:24][CH3:25])[CH:20]=3)[NH:14][C:12]2=[O:13])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1385874-Chlorobenzenesulfonyl isocyanateHCID 2779305-Methoxyanthranilic acid

Product 1

HCID 18971531HCID 18971531, compoundYield 64.8%

Procedure

1.00 g (4.59 mmol) of 4-chlorobenzenesulfonylisocyanate and 698 mg (4.18 mmol) of 2-amino-5-methoxybenzoic acid were treated in the same way as in Example 1 to obtain 992 mg of the above-identified compound (yield 64.8%). Properties: colorless crystal, Melting point: 192°-194° C., PMR (δppm, DMSO-d6): 3.79 (3H,s), 7.08 (1H,d), 7.30 (2H,m), 7.75 (2H,d), 8.16 (2H,d), 11.48 (1H,br).

Sources & evidence

ORD record
ord-602ba9cd19bc42c0924faef763947d6a
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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