2-Amino-4-chlorobenzoic acid → HCID 18971373, compound

HRID 2395278Notes

Reaction equation

HRID 2395278 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]=[C:14]=[O:15])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:16][C:17]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:18]=1[C:19]([OH:21])=O>>[Cl:26][C:24]1[CH:25]=[C:17]2[C:18]([C:19](=[O:21])[N:13]([S:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)(=[O:11])=[O:12])[C:14](=[O:15])[NH:16]2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 12618837HCID 12618837, compound

Product 1

HCID 18971373HCID 18971373, compoundYield 32.3%

Procedure

1.13 g (4.95 mmol) of 4-nitrobenzenesulfonylisocyanate and 849 mg (4.95 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 610 mg of the above-identified compound (yield 32.3%). Properties: colorless crystal, Melting point: >250° C., PMR (δppm, DMSO-d6): 7.13 (1H,s), 7.24 (1H,d), 7.87 (1H,d), 8.42 (2H,d), 8.48 (2H,d), 11.93 (1H,br).

Sources & evidence

ORD record
ord-599c500aea1147759c6f0b6e003f6eca
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

Loading…