2-Amino-4-chlorobenzoic acid → 7-choro-3-(4-fluorobenzenesulfonyl)-2,4(1H,3H)-quinazolinedione

Participants

Reaction Steps

1.72 g (8.57 mmol) of 4-fluorobenzenesulfonylisocyanate and 1.47 g (8.57 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 815 mg of the above-identified compound (yield 26.8%). Properties: colorless crystal, Melting point: >250° C., PMR (δppm, DMSO-d6): 7.12 (1H,s), 7.23 (1H,d), 7.49-7.55 (2H,m), 7.86 (1H,d), 8.23-8.28 (2H,m), 11.90 (1H,br).

Provenance & Evidence