HCID 15524163, compound → HCID 18971551, compound

HRID 2395289Notes

Reaction equation

HRID 2395289 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]([O:15]C2C=CC=CC=2)=O)[CH:3]=1.[CH3:22][N:23]1[CH:27]=[CH:26][C:25]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:24]1>>[CH3:22][N:23]1[CH:27]=[CH:26][C:25]([S:28]([NH:31][C:13]([NH:12][C:4]2[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=2[C:6]([O:8][CH3:9])=[O:7])=[O:15])(=[O:30])=[O:29])=[CH:24]1

Participants

3

Reactant 2

HCID 15524163HCID 15524163, compoundHCID 18971464HCID 18971464, compound

Product 1

HCID 18971551HCID 18971551, compound

Procedure

As the starting substances, methyl 4-chloro-2-phenoxycarbonylaminobenzoate and 1-methylpyrrole-3-sulfonamide were used and the same method was applied as in Example 36 to obtain N-(1-methylpyrrole-3-sulfonyl)-N'-(2-methoxycarbonyl-5-chlorophenyl)urea and further to obtain from 1.89 g (5.08 mmol) of N-(1-methylpyrrole-3-sulfonyl)-N'-(2-carboxy-5-chlorophenyl)urea 712 mg of the above-identified compound (yield 41.3%). Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6):3.71 (3H,s), 6.61 (1H,s), 6.90 (1H,s), 7.12 (1H,s), 7.23 (1H,d), 7.72 (1H,s), 7.86 (1H,d), 11.59 (1H,br).

Sources & evidence

ORD record
ord-fb6a5df5592f45ef8c4f4f8d6fdb90bd
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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