4-Chlorobenzenesulfonyl isocyanate → HCID 18971503, compound

HRID 2395293Notes

Reaction equation

HRID 2395293 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[C:17]([NH:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)[CH:16]=1>>[Cl:14][C:15]1[CH:16]=[C:17]2[C:18]([C:19](=[O:21])[N:11]([S:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)(=[O:9])=[O:10])[C:12](=[O:13])[N:24]2[CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 1385874-Chlorobenzenesulfonyl isocyanateHCID 18971460HCID 18971460, compound

Product 1

HCID 18971503HCID 18971503, compoundYield 36%

Procedure

950 mg (4.35 mmol) of 4-chlorobenzenesulfonylisocyanate and 950 mg (3.61 mmol) of 4-chloro-2-(2-pyridylmethyl)aminobenzoic acid were treated in the same way as in Example 1 to obtain 600 mg of the above-identified compound (yield 36.0%). Properties: colorless crystal, Melting point: >180° C. (decomposition), PMR (δppm, DMSO-d6):5.29 (2H,s), 7.3-7.5 (4H,rn), 7.7-7.8 (3H,m), 7.97 (1H,d), 8.17 (2H,d), 8.48 (1H,d)

Sources & evidence

ORD record
ord-98fb2f5554074a4898c81954562376b1
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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