HCID 15524163, compound → N-(pyrrole-2-sulfonyl)-N'-(2-methoxycarbonyl-5-chlorophenyl)urea
Reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]([O:15]C2C=CC=CC=2)=O)[CH:3]=1.[NH:22]1[CH:26]=[CH:25][CH:24]=[C:23]1[S:27]([NH2:30])(=[O:29])=[O:28]>>[NH:22]1[CH:26]=[CH:25][CH:24]=[C:23]1[S:27]([NH:30][C:13]([NH:12][C:4]1[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])=[O:15])(=[O:29])=[O:28]Participants
3
Procedure
As the starting substances, methyl 4-chloro-2-phenoxycarbonylaminobenzoate and pyrrole-2-sulfonamide were used and the same method was applied as in Example 36 to obtain N-(pyrrole-2-sulfonyl)-N'-(2-methoxycarbonyl-5-chlorophenyl)urea and further to obtain from 750 mg (2.16 mmol) of N-(pyrrole-2-sulfonyl)-N'-(2-carboxyl-5-chlorophenyl)urea 550 mg of the above-identified compound (yield 77.3%). Properties: colorless crystal, Melting point: >280° C. (decomposition), PMR (δppm, DMSO-d6):7.10 (1H,s), 7.24 (1H,d), 7.73 (1H,t), 7.85 (1H,d), 8.50 (1H,d), 7.93 (1H,d), 9.23 (1H,s), 11.68 (1H,s).
Sources & evidence
- ORD record
- ord-d807529700cc4a43b3a7c7ed760fc94a
- Source dataset
- uspto-grants-1998_09
- Patent number
- US05814631
Reaction notes
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