2-Amino-4-chlorobenzoic acid → HCID 18971504, compound

HRID 2395297Notes

Reaction equation

HRID 2395297 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[NH2:15][C:16]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=O>>[Cl:25][C:23]1[CH:24]=[C:16]2[C:17]([C:18](=[O:20])[N:12]([S:9]([C:6]3[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)(=[O:11])=[O:10])[C:13](=[O:14])[NH:15]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 18971369HCID 18971369, compound

Product 1

HCID 18971504HCID 18971504, compoundYield 17.6%

Procedure

1.14 g (5.49 mmol) of 4-cyanobenzenesulfonylisocyanate and 943 mg (5.50 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 349 mg of the above-identified compound (yield 17.6%). Properties: colorless crystal, Melting point: >250° C. (decomposition), PMR (δppm, DMSO-d6):7.13 (1H,s), 7.24 (1H,d), 7.86 (1H,d), 8.16 (2H,d), 8.32 (2H,d), 11.9 (1H,br).

Sources & evidence

ORD record
ord-f91a2d09c0d24f89abc8a0d65fab7ff1
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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