2-Amino-4-chlorobenzoic acid → 7-chloro-3-(2,5-dichlorobenzenesulfonyl)-2,4(1H,3H)-quinazolinedione

Participants

Reaction Steps

1.12 g (4.42 mmol) of 2,5-dichlorobenzenesulfonylisocyanate and 882 mg (4.42 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 1.06 g of the above-identified compound (yield 58.6%). Properties: colorless crystal, Melting point: 254°-256° C., PMR (δppm, DMSO-d6):7.17 (1H,s), 7.24 (1H,d), 7.71 (1H,d), 7.80-7.89 (2H,m), 8.18 (1H,s).

Provenance & Evidence