2-Amino-4-chlorobenzoic acid → 7-chloro-3-(2,6-dichlorobenzenesulfonyl)-2,4(1H,3H)-quinazolinedione

Participants

Reaction Steps

1.12 g (4.42 mmol) of 2,6-dichlorobenzenesulfonylisocyanate and 882 mg (4.42 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 725 mg of the above-identified compound (yield 40.5%). Properties: colorless crystal, Melting point: 260°-261° C., PMR (δppm, DMSO-d6):7.18 (1H,s), 7.22 (1H,br), 7.63 (3H,br), 7.88 (1H,d), 11.83 (1H,br).

Provenance & Evidence