2-Amino-4-chlorobenzoic acid → HCID 18971433, compound

HRID 2395303Notes

Reaction equation

HRID 2395303 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[C:4]([F:14])[CH:3]=1.[NH2:15][C:16]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=O>>[Cl:25][C:23]1[CH:24]=[C:16]2[C:17]([C:18](=[O:20])[N:11]([S:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=3[F:14])(=[O:10])=[O:9])[C:12](=[O:13])[NH:15]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 18971540HCID 18971540, compound

Product 1

HCID 18971433HCID 18971433, compoundYield 40%

Procedure

1.12 g (4.77 mmol) of 4-chloro-2-fluorobenzenesulfonylisocyanate and 819 mg (4.77 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 742 mg of the above-identified compound (yield 40.0%). Properties: colorless crystal, Melting point: 267°-268° C., PMR (δppm, DMSO-d6):7.16 (1H,s), 7.24 (1H,d), 7.56 (1H,t), 7.73 (1H,d), 7.87 (1H,d), 8.10 (1H,t), 12.2 (1H,br).

Sources & evidence

ORD record
ord-48ac71f92c4d454f9e3927a98cb4dd21
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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