2-Amino-4-chlorobenzoic acid → HCID 18971418, compound

HRID 2395305Notes

Reaction equation

HRID 2395305 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH2:17][C:18]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:19]=1[C:20]([OH:22])=O>>[Cl:27][C:25]1[CH:26]=[C:18]2[C:19]([C:20](=[O:22])[N:12]([S:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:16])([F:1])[F:15])=[CH:8][CH:7]=3)(=[O:10])=[O:11])[C:13](=[O:14])[NH:17]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 666462-Amino-4-chlorobenzoic acidHCID 18971515HCID 18971515, compound

Product 1

HCID 18971418HCID 18971418, compoundYield 32.9%

Procedure

1.67 g (6.67 mmol) of 4-trifluoromethylbenzenesulfonylisocyanate and 1.14 g (6.67 mmol) of 2-amino-4-chlorobenzoic acid were treated in the same way as in Example 1 to obtain 888 mg of the above-identified compound (yield 32.9%). Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6):7.13 (1H,s), 7.23 (1H,d), 7.87 (1H,d), 8.06 (2H,d), 8.39 (2H,d), 11.78 (1H,br).

Sources & evidence

ORD record
ord-0b02d3ea0bdd48849ad1cd11a65de485
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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