HCID 18971450, compound → HCID 18971423, compound

HRID 2395311Notes

Reaction equation

HRID 2395311 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]([NH:13][C:14]([O:16]C2C=CC=CC=2)=O)[CH:3]=1.[C:23]1([N:29]2[CH2:34][CH2:33][N:32]([CH2:35][CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([S:44]([NH2:47])(=[O:46])=[O:45])=[CH:40][CH:39]=3)[CH2:31][CH2:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([N:29]2[CH2:30][CH2:31][N:32]([CH2:35][CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([S:44]([NH:47][C:14]([NH:13][C:4]4[CH:3]=[C:2]([Cl:1])[CH:12]=[CH:11][C:5]=4[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:16])(=[O:46])=[O:45])=[CH:40][CH:39]=3)[CH2:33][CH2:34]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 18971450HCID 18971450, compoundHCID 22347443HCID 22347443, compound

Product 1

HCID 18971423HCID 18971423, compound

Procedure

As the starting substances, ethyl 4-chloro-2-phenoxycarbonylaminobenzoate and 4-[2-(4-phenylpiperazin-1-yl)ethyloxy)benzenesulfonamide were used and the same method was applied as in Example 36 to obtain N-{4-[2-(4-phenylpiperazin-1-yl)ethyloxy] benzenesulfonyl}-N'-(2-ethyloxycarbonyl-5-chlorophenyl)urea and to obtain from 813 mg (1.39 mmol) of N-{4-(2-(4-phenylpiperazin-1-yl)ethyloxy] benzenesulfonyl}-N'-(2-carboxy-5-chlorophenyl)urea 115 mg of the above-identified compound (yield 15.3%). Properties: colorless crystal, Melting point: 177°-179° C., PMR (δppm, DMSO-d6):2.65 (4H,t), 2.80 (2H,t), 3.13 (4H,t), 4.26 (2H,t), 6.75 (1H,t), 6.90 (2H,d), 7.12 (1H,s), 7.17-7.22 (5H,m), 7.85 (1H,d), 8.10 (2H,d), 11.59 (1H,br).

Sources & evidence

ORD record
ord-1a3c697f08f04354ab6f16c943049dd2
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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