Sulfanilamide → Methyl 2-{[(4-aminobenzenesulfonylamino)carbonyl]amino}-4-chlorobenzoate

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Reaction Steps

As the starting substances, methyl 4-chloro-2-phenoxycarbonylaminobenzoate and 4-aminobenzenesulfonamide were used and the same method was applied as in Example 36 to obtain N-(4-aminobenzenesulfonyl)-N'-(2-methoxycarbonyl-5-chlorophenyl)urea and further to obtain from 470 mg (1.27 mmol) of N-(4-aminobenzenesulfonyl)-N'-(2-carboxy-5-chlorophenyl)urea 270 mg of the above-identified compound (yield 60.5%). Properties: colorless crystal, Melting point: >250° C. (decomposition), PMR (δppm, DMSO-d6):6.39 (2H,s), 6.63 (2H,d), 7.09 (1H,s), 7.22 (2H,d), 7.76 (2H,d), 7.83 (2H,d), 11.51 (1H,s).

Provenance & Evidence