HCID 15524163, compound → HCID 178497888, compound

HRID 2395315Notes

Reaction equation

HRID 2395315 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]([O:15]C2C=CC=CC=2)=O)[CH:3]=1.[NH:22]1[C:26]([C:27]2[CH:32]=[CH:31][C:30]([S:33]([NH2:36])(=[O:35])=[O:34])=[CH:29][CH:28]=2)=[N:25][N:24]=[N:23]1>>[NH:25]1[C:26]([C:27]2[CH:32]=[CH:31][C:30]([S:33]([NH:36][C:13]([NH:12][C:4]3[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=3[C:6]([O:8][CH3:9])=[O:7])=[O:15])(=[O:34])=[O:35])=[CH:29][CH:28]=2)=[N:22][N:23]=[N:24]1

Participants

3

Reactant 2

HCID 15524163HCID 15524163, compoundHCID 178514699HCID 178514699, compound

Product 1

HCID 178497888HCID 178497888, compound

Procedure

As the starting substances, methyl 4-chloro-2-phenoxycarbonylaminobenzoate and 4-(5-tetrazolyl) benzenesulfonamide were used and the same method was applied as in Example 36 to obtain N-[4-(5-tetrazolyl)benzenesulfonyl]-N'-(2-methoxycarbonyl-5-chlorophenyl)urea and further to obtain from 2.00 g (4.44 mmol) of N-[4-(5-tetrazolyl)benzenesulfonyl]-N'-(2-carboxyl-5-chlorophenyl)urea 602 mg of the above-identified compound (yield 33.5%). Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6):7.14 (1H,s), 7.24 (1H,d), 7.87 (2H,d), 8.34 (4H,q), 11.66 (1H,br).

Sources & evidence

ORD record
ord-f2a6dc673673487885a2ff21ff4f93b5
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

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